Highly motivated high school students will be selected for the Big Thinkers program: a two-year mentored apprenticeship in world-class University of Chicago labs. Big Thinkers will undertake an immersive research experience with one-on-one guidance from graduate student mentors and inspirational visits from TTT Scholars: eminent scientists from STEM-underrepresented groups. By making our Big Thinkers a part of the research process, we hope to ignite students’ passion for science and create the next generation of ‘thought leaders’ in STEM.